The Principal Scientist Pharmacology in the Translational Sciences group will report to the Executive Director of Research and be a key member of the team and will partner with internal team leaders and external partners to develop and implement research on Translational Read-Through-Inducing Drug (TRID) programs. The ideal candidate will have a fundamental understanding and strong perspective of genetics, functional translational read through, pharmacology and experience as a contributing member of several pharmacology programs, with minimal supervision, from research/discovery to candidate selection.
· Provide strong scientific expertise and effective leadership to the discovery research efforts and team members.
· Play a key role in determining the mechanism of action of lead molecules.
· Provide strategic insights for pharmacology programs in discovery through transition to development.
· Work closely with development team members, when needed, to propose and develop clinically relevant biomarkers.
· Recommend, oversee and manage CRO(s), vendors and academic collaborators to ensure that all studies are performed in a quality, timely and scientific manner.
· In collaboration with management and research/discovery team members design, manage and interpret results of in vitro and in vivo studies to inform clinical development.
· Communicate results effectively through written reports and presentations with stakeholders.
· Maintain a command of relevant scientific literature.
· Ensure that the team maintains clear, detailed, and up-to-date records of research.
· Maintain an atmosphere that is open to sharing ideas and listening to the contributions of others.
· Ability to work well in a fast paced, innovative and performance driven environment.
· Demonstrated ability to simultaneously work on complex projects requiring an in-depth evaluation
of multiple, interdependent factors.
· Ability to prioritize responsibilities and meet deadlines.
· Ability to self-motivate and work independently.
· Attention to detail, experience in monitoring work to assure quality, accuracy and thoroughness.
· Outstanding communication skills with the ability to effectively converse with a variety of audiences including team members, cross-functional project teams, project leaders, and senior management.
· Ability to work at the strategic and tactical level.
· Demonstrated ability to contribute successfully in a multi-disciplinary team environment while
serving as a team lead.
· Excellent problem-solving abilities with a focus on accomplishing company goals and objectives
in a dynamic business environment.
· Ability to present thoughts clearly and concisely to a wide variety of stakeholders including senior management, directors, and corporate partners.
· Strong focus and drive to succeed.
· PhD in, Molecular Biology, Pharmacology, or related field required plus 6-8 years of industry experience in in vitro/in vivo pharmacology (experience working in a fast paced, small biotech environment is essential).
· Experience developing cell-based models of human disease. Including, but not limited to primary cell assays, iPSCs, CRISPR generated cells and organoids.
· Project leadership experience with successfully taking small molecules from early stage discovery to development decisions.
· Extensive knowledge in functional translational read-through and pharmacology.
· Experience working with CROs is essential.
· Experience in developing robust biological assays and decision-enabling experiments.
· Outstanding written and oral communication skills are essential.
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