Principal/Sr. Scientist, Pharmacology, Translational Sciences

  • Massachusetts (MA)
  • 40
  • Mon, Tue, Wed, Thu, Fri



The Role:

The Principal Scientist Pharmacology in the Translational Sciences group will report to the Executive Director of Research and be a key member of the team and will partner with internal team leaders and external partners to develop and implement research on Translational Read-Through-Inducing Drug (TRID) programs. The ideal candidate will have a fundamental understanding and strong perspective of genetics, functional translational read through, pharmacology and experience as a contributing member of several pharmacology programs, with minimal supervision, from research/discovery to candidate selection.



·       Provide strong scientific expertise and effective leadership to the discovery research efforts and team members.

·       Play a key role in determining the mechanism of action of lead molecules.

·       Provide strategic insights for pharmacology programs in discovery through transition to development.

·       Work closely with development team members, when needed, to propose and develop clinically relevant biomarkers.

·       Recommend, oversee and manage CRO(s), vendors and academic collaborators to ensure that all studies are performed in a quality, timely and scientific manner.

·       In collaboration with management and research/discovery team members design, manage and interpret results of in vitro and in vivo studies to inform clinical development.

·       Communicate results effectively through written reports and presentations with stakeholders.

·       Maintain a command of relevant scientific literature.

·       Ensure that the team maintains clear, detailed, and up-to-date records of research.

·       Maintain an atmosphere that is open to sharing ideas and listening to the contributions of others.

Competencies Include:

·       Ability to work well in a fast paced, innovative and performance driven environment.

·       Demonstrated ability to simultaneously work on complex projects requiring an in-depth evaluation

of multiple, interdependent factors.

·       Ability to prioritize responsibilities and meet deadlines.

·       Ability to self-motivate and work independently.

·       Attention to detail, experience in monitoring work to assure quality, accuracy and thoroughness.

·       Outstanding communication skills with the ability to effectively converse with a variety of audiences including team members, cross-functional project teams, project leaders, and senior management.

·       Ability to work at the strategic and tactical level.

·       Demonstrated ability to contribute successfully in a multi-disciplinary team environment while

serving as a team lead.

·       Excellent problem-solving abilities with a focus on accomplishing company goals and objectives

in a dynamic business environment.

·       Ability to present thoughts clearly and concisely to a wide variety of stakeholders including senior management, directors, and corporate partners.

·       Strong focus and drive to succeed.


·       PhD in, Molecular Biology, Pharmacology, or related field required plus 6-8 years of industry experience in in vitro/in vivo pharmacology (experience working in a fast paced, small biotech environment is essential).

·       Experience developing cell-based models of human disease. Including, but not limited to primary cell assays, iPSCs, CRISPR generated cells and organoids.

·       Project leadership experience with successfully taking small molecules from early stage discovery to development decisions.

·       Extensive knowledge in functional translational read-through and pharmacology.

·       Experience working with CROs is essential.

·       Experience in developing robust biological assays and decision-enabling experiments.

·       Outstanding written and oral communication skills are essential.

Login to read more

About the Client

  • 3 jobs posted
  • 0 hired



Related Projects

More Projects

© 2019